Friday, January 20, 2006

Fighting the Bovine Disease of Cattle

Agricultural Research Service (ARS) scientists are ready to take to the nextlevel efforts to eradicate the bovine viral diarrhea virus (BVDV). BVDV causes animal diseases that affect reproduction and nutrition, milkproduction and respiratory function.

Pregnant cows that are infected can havespontaneous abortions or give birth prematurely, while calves born with BVDV maybe persistent carriers that can infect additional herds. There's no treatment for BVDV, which costs U.S. cattle producers millions ofdollars in losses each year.

According to microbiologist Julia Ridpath of ARS’ National Animal Disease Centerin Ames, Iowa, decades of vaccination and voluntary control programs aimed ateliminating the virus from the United States have not worked. Also at Ames, microbiologist John Neill is applying a method that detectsalterations in cancer cells in humans toward understanding disease mechanisms inanimals infected with the virus.

An extensive management program encompassing vigilance, biosecurity educationand continued research is needed, according to Ridpath. She recently launched astudy with the Northeast Iowa Community-Based Dairy Foundation in Calmar,focusing on newborn calves’ response to BVDV vaccination. This study is thesubject of a cooperative research and development agreement that runs through2006.

Meanwhile, Neill is applying serial analysis of gene expression (SAGE) -- atechnology developed in the mid-1990s for detecting gene-expression alterationsthat tell how cancer cells differ from normal cells -- against BVDV. Neill is using SAGE to compare cattle gene expression in normal cells to that inBVDV-infected cells.

He’s also studying the pathology and immunosuppressiveproperties of the virus -- work that may lead to a simple serum test for rapidlydetecting persistently infected animals and improved vaccines.

Read more about the research in the January 2006 issue of Agricultural Researchmagazine, available online at: http://www.ars.usda.gov/is/AR/archive/jan06/bovine0106.htm


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AGRI-INFO/JANUARY 20, 2006



TITLE: NEW APPROACHES NEEDED TO FIGHT THIS CATTLE VIRUS


ALAM BA NINYO NA MERONG MGA BAGONG PARAAN ANG MGA EKSPERTO PARA MALABANAN ANG BOVINE VIRAL DIARRHEA VIRUS (DVDV)?

ANG BVDV AY SIYANG SANHI NG SAKIT SA HAYOP NA MALAKI ANG EPEKTO SA REPRODUCTION AT NUTRITION, MAGING NA MILK PRODUCTION AT RESPIRATORY FUNCTION NG ALAGA NATING HAYOP.

ANG MGA BAKANG BUNTIS NA MERON NG GANITONG SAKIT AY POSIBLENG MAKUNAN O KAYA AY PRE MATURE ANG PANGANGANAK NITO.

MAGING ANG MGA NAIPANGANAK NANG BAKA NA MERONG BVDV AY MAAARING MAGING CARRIER OTAGAPAGDALA NG NATURANG SAKIT AT MAKAKAAPEKTO SA IBA PANG URI NG HAYOP.

INAMIN NI MICROBIOLOGIST JULIA RIDPATH NG ARS NATIONAL ANIMAL DISEASE CENTER, NA ILANG DEKADA NA ANG GINUGOL NG MGA SIYENTISTA PARA SA PAGBABAKUNA AT IBAPANG CONTROL PROGRAMS NGUNIT HINDI ITO UMUBRA.

NGUNIT, SA KATUNAYAN, WALA PA TALAGANG GAMOT LABAN SA BVDV NA SIYANG DAHILAN KUNG BAKIT MARAMI ANG MGA MAGSASAKA ANG SUMASAKIT ANG ULO SA SAKIT NA ITO SA BAKAHAN.

AYON KAY RIDPATH, KAILANGAN LAMANG ANG EXTENSIVE MANAGEMENT PROGRAM TULAD NG VIGILANCE, BIOSECURITY EDUCATION AT PATULOY NA RESEARCH SA NATURANG PROBLEMA.

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