Thursday, January 05, 2006

New Antibiotic for Bacterial Honey Bee Disease

American beekeepers will soon have a new antibiotic with which to protect their colonies from American foulbrood disease, thanks to Agricultural Research Service (ARS) studies that paved the way for the compound's regulatory approval.

TYLAN Soluble (tylosin tartrate), produced by Elanco Animal Health of Greenfield, Ind., was approved for use October 20 by the U.S. Food and Drug Administration, following the agency's review of research data compiled by scientists with the ARS Bee Research Laboratory in Beltsville, Md.

American foulbrood is among the most widespread and devastating diseases of honey bees. Caused by the bacterium Paenibacillus larvae, the disease kills young bee larvae and transforms their remains into dark, shriveled ropes or "scales." These contain billions of spores that are easily spread by nurse bees.

Although American foulbrood poses no human danger, severe outbreaks can weaken or kill entire bee colonies, according to Mark Feldlaufer, who leads the ARS Beltsville bee lab.Before tylosin tartrate, only one other antibiotic, oxytetracycline hydrochloride (Terramycin), was available for use against American foulbrood.

However, reliance on this one compound has prompted the emergence of resistant strains of American foulbrood.Tylosin tartrate is already approved for therapeutic use in chickens and swine, and as a feed-efficiency aid in turkeys.

Its approval for honey bees marks a first for a so-called minor animal species. Feldlaufer's team made this approval possible by furnishing the FDA with a wealth of information on tylosin tartrate's field efficacy and safety, both for honey bees and humans. For example, the team determined the necessary dosage, application methods and timing of treatment in honey bee hives.

Although the drug approval labels honey bees as a "minor animal species," the bee\'s importance to U.S. agriculture is hardly minor. By one estimate, honey bee pollination of apples, almonds, blueberries and many other agricultural crops results in yield and quality improvements valued at more than $14 billion annually.


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AGRI-INFO/JANUARY 5, 2006



TITLE: NEW ANTIBIOTIC APPROVED FOR TREATING BACTERIAL HONEY BEE DISEASE


ALAM BA NINYO NA MERON NANG BAGONG ANTI-BIOTIC NA MAGBIBIGAY NG PROTEKSIYON SA HONEY BEE LABAN SA MAPAMUKSANG FOULBROOD DISEASE?

ITO AY BATAY SA GINAWANG PANANALIKSIK NG MGA EKSPERTO NG AGRICULTURAL RESEARCH SERVICE PARA MAKATULONG SA MGA BEEKEEPER HINDI LAMANG SA US KUNDI SA BUONG MUNDO.

TI NUKOY DITO ANG ANTIBIOTIC NA TYLAN SOLUBLE (TYLOSIN TARTRATE) NA GINAWA NG ELANCO ANIMAL HEALTH OF GREENFIELD AT APRUBADO NG US FOOD AND DRUG ADMINISTRATION.

ANG AMERICAN FOULBROOD AY ISA SA PINAKAMATITINDI AT MAPAMINSALANG SAKIT NG HONEYBEES, DULOT NG BACTERIUM PAENIBACILLUS LARVAE, ANG SAKIT NA PUMAPATAY SA MGA BATANG BEE LARVAE.

BAGOPAMAN NAGKAROON NG TYLOSIN TARTRATE, ANG TANGING ANTI-BIOTIC NOON AY ANG OXYTETRACYCLINE HYDROCHLORIDE (TERRAMYCIN) NA UNANG GINAGAMIT NOON LABAN SA AMERICAN FOULBROOD.

NGUNIT, SUMIBOL ANG MGA BAGONG URI NG PESTE NA MATIBAY SA NATURANG URI NG ANTIBAYOTIKO, KUNG KAYAT GUMAWA NG PARAAN ANG MGA SIYENTISTA NA MAGKAROON NG BAGONG GAMOT LABAN SA PESTE.

ANG TYLOSIN TARTRATE AY UNA NANG INAPRUBAHAN PARA SA THERAPEUTIC USAGE NG MGA MANOK AT BABOY AT NAGSISILBI DING FEED EFFICIENCY AID SA MGA PABO O TURKEY.

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