Monday, March 13, 2006

Mammals, fruit flies:same biological clock

New York University and University of London scientists say they've found more evidence that mammals and fruit flies share a common genetic makeup.

Drosophila fruit flies are commonly used for research on biological, or circadian, clocks because of the relative ease of finding mutants with non-24-hour rhythms and then identifying the genes underlying the altered behavior.

The NYU and London studies of fruit flies have allowed the identification of "clock genes" in mammals, which function in a similar manner in mammals as they do in a fly's clock. However, prior to the study, biologists had concluded that the role of one protein -- Cryptochrome, called Cry -- was quite different between flies and mammals.

In fruit flies, Cry is a circadian photoreceptor, which helps light reset the biological clock with changing seasons. In mammals, however, Cry assists in the 24-hour rhythmic expression of clock genes and has nothing to do with re-setting the clock. The study appears in the latest issue of Current Biology.

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AGRI-INFO/MARCH 13, 2006


TITLE: MAMMALS, FRUIT FLIES SHARE SAME BIOLOGICAL CLOCK

ALAM BA NINYO NA ANG MGA HAYOP O MAMMALS AY MERONG IISANG TINATAWAG NA GENETIC MAKEUP SA FRUIT FLIES?

ITO ANG NATUKLASAN NG MGA EKSPERTO MULA SA NEW YORK UNIVERSITY AT UNIVERSITY OF LONDON KAUGNAY NG KANILANG PANANALIKSIK NA GINAWA SA KAUGNAYAN NG MGA HAYOP SA PARTIKULAR NA DROSOPHILA FRUIT FLIES.

ANG DROSOPHILA FRUIT FLIES AY KARANIWANG GINAGAMIT SA RESEARCH NG BIOLOGICAL, O KAYA AY SA CIRCADIAN CLOCKS DAHIL SA SINASABING RELATIVE EASE NA MAKATAGPO NG MUTANT SA NON-24 HOUR RHYTHMS AT ANG PAGTUKOY SA GENES SA PAMAMAGITAN NG PAGKONTROL SA BEHAVIOR.

DITO NATUKOY NG MGA EKSPERTO ANG "CLOCK GENES" SA MAMMALS, NA UMANOY GUMAGANA KAPAREHO NG MAMMALS TULAD NG SA FLY GENE CLOCK.

GAYUNMAN, BAGO ANG GINAWANG PAG-AARAL, MAY KONKLUSYON ANG MGA BIOLOGIST NA ANG ROLE NG ISANG PROTINA - CRYPTOCHROME NA TINATAWAG DIN NG CRY AY MALAKI ANG PAGKAKAIBA SA FLIES AT MAMMALS.

SA FRUIT FLIES, ANG CRY AY ISANG CIRCADIAN PHOTORECEPTOR, NA TUMUTULONG SA LIWANAG PARA MA-RESET ANG BIOLOGICAL CLOCK SA PABAGU-BAGONG PANAHON. SA MAMMALS NAMAN, ANG CRY AY TUMUTULONG SA 24-HOUR RHYTHMIC EXPRESSION NG CLOCK GENES AT WALA ITONG KINALAMAN SA RE-SETTING NG CLOCK.

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