Monday, September 04, 2006

New Technique to Tap Bulls for Breeding

A project involving Agricultural Research Service (ARS) and collaborating scientists could open the door to a new, genomics-based approach to identifying elite bulls.Now carried out by the artificial insemination (AI) industry, progeny testing characterizes the genetic merit of a bull. But progeny testing is time-consuming and expensive.

Each year, AI organizations test 1,200 Holstein dairy bulls at a cost of about $30 million.Cutting test costs while increasing the rate of genetic improvement in dairy cattle could help make the U.S. germplasm industry even more competitive in the world market, according to Curt Van Tassell. He's a geneticist working with the ARS Bovine Functional Genomics Research Unit and the ARS Animal Improvement Programs Laboratory, both in Beltsville, Md.

Records on performance and conformation are combined with pedigree information using sophisticated statistical methods to determine the genetic merit of animals used for breeding. But Van Tassell and ARS collaborators Tad Sonstegard and George Wiggans are investigating an approach called "genome-enhanced selection" which could replace progeny testing and cost around $500 per bull.

Central to the approach is obtaining information on DNA sequence variations, or genetic markers, called single nucleotide polymorphisms (SNPs). Efforts are under way to develop a test to allow close examination of 55,000 SNPs from a select group of 4,000 animals representing several dairy breeds and an ARS research population.

The scientists will then correlate the SNP data to observable, or phenotypic, traits of interest so that eventually dairy producers can use information derived from the markers to selectively breed animals based on genetic merit.Collaborating with the Beltsville team are professors Jerry Taylor with the University of Missouri-Columbia and Stephen Moore with the University of Alberta-Edmonton, Canada; and Illumina, Inc., of San Diego, Calif.

The ARS labs have cooperative agreements with the National Association of Animal Breeders of Columbia, Mo., and Merial Limited of Duluth, Ga. The project also received funding from the USDA-CSREES National Research Initiative.



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AGRI-INFO/SEPTEMBER 4, 2006



TITLE: NEW TECHNIQUE TO TAP BULLS FOR BREEDING


ALAM BA NINYO NA NATUKLASAN NG MGA AGRI-EXPERT ANG BAGONG TEKNIK NA NAGLALAYONG MAKATULONG NG MALAKI SA BREEDING NG INYONG MGA ALAGANG BAKA?

SA NGAYON, GINAGAMIT ANG TINATAWAG NA PROGENY TESTING SA ARTIFICIAL INSEMINATION PARA SA REPRODUCTION NG MGA BAKA.

GAYUNMAN, ANG PROGENY TESTING AY MAITUTURING NA NAPAKAMAHAL AT KAILANGANG MAGLAAN NG SAPAT NA PANAHON O ORAS.

DAHIL DITO, ISANG MAKABAGONG PAMAMARAAN NA TINAGURIANG “GENOME-ENHANCED SELECTION” AY ISINASAILALIM SA MASUSING PAG-AARAL PARA KAPALIT NG PROGENY TESTING PARA SA GENETIC IMPROVEMENT NG DAIRY CATTLE.

NAKAPALOOB DITO NA MAKAKUHA NG KAUKULANG MGA IMPORMASYON SA DNA SEQUENCE VARIATION O GENETIC MARKERS NA TINATAWAG NA SINGLE NUCLEOTIDE POLYMORPHISMS (SNPs).

SINISIKAP DIN NG MGA EKSPERTO NA MAKATUKLAS NG TESTING TECHNIQUE NA NAGLALAYONG MAGKAROON NG CLOSE EXAMINATION NG 55-LIBONG SNP MULA SA PINILING GRUPO NG 4-LIBONG MGA HAYOP NA KUMAKATAWAN SA IBAT-IBANG DAIRY BREEDS AT RESEARCH POPULATION.

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